The aim of this research is to apply the meta-synthesis technique to identify safety, health, and environmental indicators in the value-added model of the petrochemical industry supply chain. In the petrochemical industry, safety, health, and the environment hold significant importance. Safety indicators such as work accident rates, safety training, and the use of protective equipment can indicate operational sustainability in the petrochemical industry. The researcher employed a systematic review and meta-synthesis approach to analyze the results and findings of previous researchers. By following the seven-step method of Sandelowski and Barroso, influential factors were identified. Out of 556 articles, 55 were selected based on the CASP method, and the validity of the analysis was confirmed with a Kappa coefficient of 0.711. To assess reliability and quality control, the transcription method was used, which revealed an excellent agreement level for the identified indicators. The results of the collected data analysis using MAXQDA software led to the identification of 84 initial codes in 16 categories. The 16 criteria are: political factors, cultural factors, legal factors, financial factors, individual factors, managerial factors, information resources, implementation, review, feedback analysis, performance evaluation factors, risk concepts, identification of environmental issues, identification of health issues, learning about safety topics, and the value-added supply chain of the petrochemical industry with a sustainable development approach. In the value-added model of the petrochemical industry supply chain, safety, health, and environmental indicators are of great importance. Safety in these industries is essential, as non-compliance with safety standards can lead to serious incidents, including personal and environmental damage. Therefore, adherence to safety standards and training, along with the development of safety technologies, can lead to significant improvements in this industry. Additionally, the health of employees and maintaining their well-being is another priority of this supply chain. Creating a healthy work environment and providing appropriate health services to workers can play a crucial role in increasing productivity and reducing injury rates caused by working conditions.